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    Satb2 SATB homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501145, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Satb2provided by RGD
    Official Full Name
    SATB homeobox 2provided by RGD
    Primary source
    RGD:1562369
    See related
    EnsemblRapid:ENSRNOG00000010188 AllianceGenome:RGD:1562369
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562369
    Summary
    Enables histone deacetylase binding activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including generation of neurons; regulation of transcription by RNA polymerase II; and skeletal system development. Predicted to be located in nucleoplasm. Predicted to be part of histone deacetylase complex and transcription regulator complex. Human ortholog(s) of this gene implicated in SATB2-associated syndrome. Orthologous to human SATB2 (SATB homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 37.1), Brain (RPKM 36.2) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    9q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (65842351..66028569, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (58348027..58534256, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (63456877..63642193, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene heat shock transcription factor, Y linked 2 Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC102549320 Neighboring gene uncharacterized LOC120094688 Neighboring gene uncharacterized LOC102549484 Neighboring gene similar to human chromosome 2 open reading frame 69

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MiR-1301 promotes adipogenic and osteogenic differentiation of BMSCs by targeting Satb2. Kong J, et al. Eur Rev Med Pharmacol Sci, 2020 Apr. PMID 32329823
    2. Maternal regulation of SATB2 in osteo-progeniters impairs skeletal development in offspring. Chen JR, et al. FASEB J, 2020 Feb. PMID 31908011
    3. MicroRNA-449b-5p promotes the progression of osteoporosis by inhibiting osteogenic differentiation of BMSCs via targeting Satb2. Li JY, et al. Eur Rev Med Pharmacol Sci, 2019 Aug. PMID 31378877
    4. The sympathetic neurotransmitter switch depends on the nuclear matrix protein Satb2. Apostolova G, et al. J Neurosci, 2010 Dec 1. PMID 21123581, Free PMC Article
    5. Estrogen regulates stemness and senescence of bone marrow stromal cells to prevent osteoporosis via ERβ-SATB2 pathway. Wu G, et al. J Cell Physiol, 2018 May. PMID 29030963

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-1301 promotes adipogenic and osteogenic differentiation of BMSCs by targeting Satb2.
      Title: MiR-1301 promotes adipogenic and osteogenic differentiation of BMSCs by targeting Satb2.
    2. Maternal regulation of SATB2 in osteo-progeniters impairs skeletal development in offspring.
      Title: Maternal regulation of SATB2 in osteo-progeniters impairs skeletal development in offspring.
    3. MicroRNA-449b-5p promotes the progression of osteoporosis by inhibiting osteogenic differentiation of BMSCs via targeting Satb2.
      Title: MicroRNA-449b-5p promotes the progression of osteoporosis by inhibiting osteogenic differentiation of BMSCs via targeting Satb2.
    4. bone marrow stromal cells from the OVX rats displayed increased senescence and weaker SATB2 expression, stemness, and osteogenic differentiation, while estrogen could rescue these phenotypes. Inhibition of ERb or ERa confirmed that SATB2 was associated with ERb in estrogen-mediated pluripotency and senescence of BMSCs.
      Title: Estrogen regulates stemness and senescence of bone marrow stromal cells to prevent osteoporosis via ERβ-SATB2 pathway.
    5. miR-34b/c participates in aldosterone-induced vascular smooth muscle cell calcification via a SATB2/Runx2 pathway.
      Title: MicroRNA-34b/c inhibits aldosterone-induced vascular smooth muscle cell calcification via a SATB2/Runx2 pathway.
    6. Satb2 may also be related to the establishment of species-specific neuropeptide co-phenotypes during postnatal development.
      Title: Satb2-independent acquisition of the cholinergic sudomotor phenotype in rodents.
    7. miR-31 diminishes the levels of the Satb2 protein without significantly affecting Satb2 mRNA levels, and Runx2 directly represses miR-31 expression, a mechanism that may play an important role in inducing osteogenic differentiation.
      Title: Effects of a miR-31, Runx2, and Satb2 regulatory loop on the osteogenic differentiation of bone mesenchymal stem cells.
    8. Matrix attachment region protein Satb2 demonstrates a function in growth factor-dependent neurotransmitter plasticity in postmitotic neurons.
      Title: The sympathetic neurotransmitter switch depends on the nuclear matrix protein Satb2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cartilage development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within osteoblast development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding protein SATB2
    Names
    special AT-rich sequence binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109306.1 → NP_001102776.1  DNA-binding protein SATB2

      See identical proteins and their annotated locations for NP_001102776.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473965
      UniProtKB/TrEMBL
      A6IP31, D3ZJ19
      Related
      ENSRNOP00000087808.2, ENSRNOT00000107325.2
      Conserved Domains (4) summary
      smart00389
      Location:614 → 671
      HOX; Homeodomain
      cd11585
      Location:60 → 155
      SATB1_N; N-terminal domain of SATB1 and similar proteins
      pfam02376
      Location:477 → 556
      CUT; CUT domain
      pfam16557
      Location:162 → 232
      CUTL; CUT1-like DNA-binding domain of SATB

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      65842351..66028569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596603.3 → XP_017452092.1  DNA-binding protein SATB2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AHD9, D3ZJ19
      Conserved Domains (4) summary
      smart00389
      Location:621 → 678
      HOX; Homeodomain
      cd11585
      Location:67 → 162
      SATB1_N; N-terminal domain of SATB1 and similar proteins
      pfam02376
      Location:484 → 563
      CUT; CUT domain
      pfam16557
      Location:169 → 239
      CUTL; CUT1-like DNA-binding domain of SATB

    2. XM_008767129.4 → XP_008765351.1  DNA-binding protein SATB2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AHD9, D3ZJ19
      Conserved Domains (4) summary
      smart00389
      Location:621 → 678
      HOX; Homeodomain
      cd11585
      Location:67 → 162
      SATB1_N; N-terminal domain of SATB1 and similar proteins
      pfam02376
      Location:484 → 563
      CUT; CUT domain
      pfam16557
      Location:169 → 239
      CUTL; CUT1-like DNA-binding domain of SATB

    3. XM_063267604.1 → XP_063123674.1  DNA-binding protein SATB2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JZH5, D3ZJ19
      Related
      ENSRNOP00000071049.2, ENSRNOT00000087684.3
    Nucleotide Protein Strain
    Heading Accession and Version

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